Publications

Pubmed search

Regulation of Lipid Homeostasis

Tong Z, Kim MS, Pandey A, and Espenshade PJ. 2014. Identification of Candidate Substrates for the Golgi Tul1 E3 Ligase Using Quantitative diGly Proteomics in Yeast. Mol Cell Proteomics 13:2871-82 [LINK]
Shao, W and Espenshade, PJ. 2014. Sterol Regulatory Element-binding Protein (SREBP) Cleavage Regulates Golgi-to-ER Recycling of SREBP Cleavage Activating Protein (SCAP). J Biol Chem. 289:7547-57 [LINK]
Brookheart RT, Lee CY, Espenshade PJ. 2013. Casein kinase 1 regulates sterol regulatory element-binding protein (SREBP) to control sterol homeostasis. J Biol Chem. 289:2725-35 [LINK]
Lloyd SJ, Raychaudhuri S, Espenshade PJ. 2013. Subunit architecture of the Golgi Dsc E3 ligase required for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast. J Biol Chem. 288:21043-54. [LINK]
Cheung R, Espenshade PJ. 2013. Structural requirements for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast. J Biol Chem. 288:20351-60. [LINK]
Stewart EV, Lloyd SJ, Burg JS, Nwosu CC, Lintner RE, Daza R, Russ C, Ponchner K, Nusbaum C, Espenshade PJ. 2012. Yeast sterol regulatory element-binding protein (SREBP) cleavage requires Cdc48 and Dsc5, a ubiquitin regulatory X domain-containing subunit of the Golgi Dsc E3 ligase. J Biol Chem. 287:672-81. [LINK]
Ryan CJ, Roguev A, Patrick K, Xu J, Jahari H, Tong Z, Beltrao P, Shales M, Qu H, Collins SR, Kliegman JI, Jiang L, Kuo D, Tosti E, Kim HS, Edelmann W, Keogh MC, Greene D, Tang C, Cunningham P, Shokat KM, Cagney G, Svensson JP, Guthrie C, Espenshade PJ, Ideker T, Krogan NJ. 2012. Hierarchical modularity and the evolution of genetic interactomes across species. Mol Cell. 46:691-704. [LINK]
Burg JS, Espenshade PJ. 2011. Glucose controls phosphoregulation of HMG-COA reductase through the PP2A-related phosphatase Ppe1 and Insig in fission yeast. J. Biol. Chem. 286:27139-46. [LINK]
Porter JR, Burg JS, Espenshade PJ, Iglesias PA. 2012. Identifying a static nonlinear structure in a biological system using noisy, sparse data. J Theor Biol. 300:232-41. [LINK]
Stewart EV, Nwosu CC, Tong Z, Roguev A, Cummins TD, Kim DU, Hayles J, Park HO, Hoe KL, Powell DW, Krogan NJ, Espenshade PJ. 2011. Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex. Mol. Cell 42:160-171. [LINK]
Porter JR, Burg JS, Espenshade PJ*, Iglesias PA*. 2010. Ergosterol regulates SREBP cleavage in fission yeast. J. Biol. Chem. 285:41051-61. *Corresponding author. [LINK]
Hughes BT, Nwosu CC, Espenshade PJ. 2009. Degradation of sterol regulatory element-binding protein precursor requires the endoplasmic reticulum-associated degradation components Ubc7 and Hrd1 in fission yeast. J Biol Chem. 284:20512-21 [LINK]
Burg JS, Powell DW, Chai R, Hughes AL, Link AJ, Espenshade PJ. 2008. Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast. Cell Metabolism 8:522-31. [LINK]
Hughes, A.L., Stewart, E.V. and Espenshade, P.J. 2008. Identification of 23 mutations in fission yeast Scap that constitutively activate SREBP. J. Lipid Research 49:2001-2012. [LINK]
Sehgal, A, Hughes, B.T., Espenshade, P.J. 2008. Oxygen-dependent, alternative promoter controls translation of tco1+ in fission yeast. Nucleic Acids Research 36:2024-2031. [LINK]
Sehgal, A., C.Y. Lee, P.J. Espenshade. 2007. SREBP controls oxygen-dependent mobilization of retrotransposons in fission yeast. PLoS Genet. 3:1389-1396. [LINK]
Hughes, A.L., C.Y. Lee, C.M. Bien, P.J. Espenshade. 2007. 4-Methyl sterols regulate fission yeast SREBP-Scap under low oxygen and cell stress. J. Biol. Chem. 282:24388-96. [LINK]
Hughes, A.L., D.W. Powell, M. Bard, J. Eckstein, R. Barbuch, A.J. Link, and P.J. Espenshade. 2007. Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes. Cell Metabolism 5:143-149. [LINK]
Todd, B.L., E.V. Stewart, J.S. Burg, A.L. Hughes, P.J. Espenshade. 2006. Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast. Mol Cell. Biol. 26:2817-2831. [LINK]
Hughes, A.L., B.L. Todd, and P.J. Espenshade. 2005. SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast. Cell 120:831-842. [LINK]

 

Oxygen Sensing

Porter JR, Lee CY, Espenshade PJ, Iglesias PA. 2012. Regulation of SREBP during hypoxia requires Ofd1-mediated control of both DNA binding and degradation. Mol Biol Cell. 23:3764-74. [LINK]
Lee CY, Yeh TL, Hughes BT, Espenshade PJ. 2011. Regulation of the Sre1 hypoxic transcription factor by oxygen-dependent control of DNA binding. Mol Cell. 44:225-34. [LINK]
Yeh TL, Lee CSY, Amzel LM, Espenshade PJ*, and Bianchet MB*. 2011. The hypoxic regulator of sterol synthesis Nro1 is a nuclear import adaptor. Structure 19:503-14. *Corresponding author. [LINK]
Lee, C.Y., Stewart, E.V., Hughes, B.T. and Espenshade, P.J. 2009. Oxygen-dependent binding of Nro1 to the prolyl hydroxylase Ofd1 regulates SREBP degradation in yeast. EMBO J. 28:135-43. [LINK]
Hughes, B.T. and Espenshade, P.J. 2008. Oxygen-regulated degradation of fission yeast SREBP by Ofd1, a prolyl hydroxylase family member. EMBO J. 27:1491-1501. [LINK]

 

Pathogenic Fungi

Bien CM, Chang YC, Nes WD, Kwon-Chung KJ, and Espenshade PJ. 2009. Cryptococcus neoformans Site-2 protease is required for virulence and survival in the presence of azole drugs. Mol. Microbiol. 74:672-690. [LINK]
Chang YC, Ingavale SS, Bien C, Espenshade PJ, and Kwon-Chung KJ. 2009. Conservation of the SREBP pathway and its pathobiological importance in Cryptococcus neoformans. Eukaryot Cell 8:1770-1779. [LINK]
Lee, H., C.M. Bien, A.L. Hughes, P.J. Espenshade, K.J. Kwon-Chung. 2007. Cobalt chloride, a hypoxia-mimicking agent, targets sterol synthesis in the pathogenic fungus Cryptococcus neoformans. Mol. Microbiol. 65:1018-1033. [LINK]
Chang, Y.C., C.M. Bien, H. Lee, P.J. Espenshade, K.J. Kwon-Chung. 2007. Sre1p, a regulator of oxygen sensing and sterol homeostasis, is required for virulence in Cryptococcus neoformans. Mol. Microbiol. 64:614-29. [LINK]

 

Reviews and Chapters

Shao W, Espenshade PJ. 2012. Expanding roles for SREBP in metabolism. Cell Metab. 16:414-9. [LINK]
Raychaudhuri S, Young BP, Espenshade PJ, Loewen C Jr. 2012. Regulation of lipid metabolism: a tale of two yeasts. Curr Opin Cell Biol. 24:502-8. [LINK]
Espenshade PJ. . Cholesterol Synthesis and Regulation. In: W.J. Lennarz and M.D. Lane (eds.) The Encyclopedia of Biological Chemistry, Elsevier Inc., Oxford.
Burg JS, Espenshade PJ. 2011. Regulation of HMG-CoA reductase in mammals and yeast. Prog. Lipid Res. 50:403–410. [LINK]
Bien CM and Espenshade PJ. 2010. Sterol regulatory element binding proteins in fungi: Hypoxic transcription factors linked to pathogenesis. Eukaryotic Cell. 9:352-9. [LINK]
Osborne TF, Espenshade PJ. 2009. Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been. Genes Dev. 22:2578-81 [LINK]
Espenshade, P.J., A.L. Hughes. 2007. Regulation of sterol synthesis in eukaryotes. Annu. Rev. Genet. 41:401-427. [LINK]
Espenshade, P.J. 2006. SREBPs: sterol-regulated transcription factors. J. Cell Sci. 119:973-976. [LINK]
Espenshade, P.J., J.L. Goldstein, and M.S. Brown. 2003. SREBPs: Gene Regulation through Controlled Protein Trafficking. In Handbook of Cellular Signaling (R. Bradshaw and E. Dennis, eds.). Academic Press, San Diego.
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